Bioidentical HRT, managed by a physician.

Estradiol + progesterone in one daily cream.

  • HSA/FSA Eligible
  • 6-mo money back guarantee
  • Free, unlimited doctor visits & messaging
Oestra® bioidentical estradiol and progesterone cream jar

Our care team will work with you until you feel better.

Have you used hormone therapy before?It will help us personalize your treatment.
4.9

Bioidentical Estradiol + Micronized Progesterone. Clinically proven & third-party tested.

50

Prescribed in 50 states. Compounded in a licensed U.S. pharmacy. NABP, LegitScript & PCAB certified.

90%

90% of patients said the Oestra® treatment changed their life.

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BUST

Here’s what happens after you order

  1. Today

    Check out today

    No insurance forms, no phone calls, no waiting rooms.

  2. Within 24 hrs

    A licensed doctor prescribes your treatment

    If anything needs clarifying, they’ll message you

  3. In 3-7 days

    Your Oestra treatment arrives

    Shipped from a US-licensed, PCAB-accredited compounding pharmacy.

  4. Months 1-6

    Meet with your clinician

    You talk through how you’re feeling and your dose gets adjusted if it needs to be. Then again whenever you want. Always included.

See if you qualify
  • HSA/FSA Eligible
  • 6-month money back guarantee
  • Free, unlimited doctor visits & messaging

Real guidance from the doctor behind Oestra®

Directly from the words of Dr. Sarah Daccarett.

After treating thousands of women, a clear pattern emerged — anxiety, poor sleep, brain fog, and low energy, often dismissed despite "normal" labs. Existing hormone therapy felt fragmented and overly complex. Oestra was created to simplify care and actually address how women feel.

Lab results don't always reflect how hormones fluctuate in real life. Many women feel unwell despite being told everything is "normal." Symptoms like brain fog, anxiety, and poor sleep are often more accurate indicators — and should guide treatment decisions.

Traditional hormone therapy often targets a few symptoms like hot flashes or sleep. Oestra takes a broader approach, supporting brain function, metabolism, energy, skin, and overall wellbeing. It's designed to help women feel fully balanced — not just manage isolated symptoms.

Hormone therapy is often fragmented into multiple prescriptions, lab tests, and trial-and-error adjustments that can take years. Oestra® was designed to simplify the process into a single, streamlined approach that fits into your life without unnecessary complexity or cost.

Oestra® combines estradiol and progesterone into one daily treatment, replacing multiple prescriptions. This makes therapy easier to follow and more effective long term.

Estradiol and progesterone work together to support the entire body — including brain health, metabolism, skin, sleep, and the nervous system. Using both helps restore balance more effectively than treating hormones in isolation.

Vaginal delivery allows hormones to be absorbed directly into the bloodstream, supporting more stable levels and consistent symptom relief. Oral and topical methods are less efficient.

Many women notice early improvements in sleep and mood within weeks, with deeper changes like skin and cognitive function improving over 2–3 months.

Your care begins with a clinician reviewing your assessment. Your prescription is compounded and shipped directly to you, with ongoing adjustments and access to clinical support as your needs evolve.

Oestra® uses bioidentical estradiol and micronized progesterone, identical to the body's natural hormones. Treatment is monitored and adjusted over time, focusing on safe, long-term support.

Oestra® restores progesterone, which the body can naturally convert into testosterone as needed. This supports balance without forcing levels and helps avoid side effects like acne, hair loss, or weight gain.

Oestra® is a prescription-based hormone therapy reviewed by a clinician and tailored to your symptoms. It's compounded in a licensed pharmacy using pharmaceutical-grade ingredients.

See if you qualify
  • HSA/FSA Eligible
  • 6-month money back guarantee
  • Free, unlimited doctor visits & messaging

FAQs

Getting Started

The first thing to do is to take our health quiz, where we will make sure you are a candidate for Oestra. From there, you’ll checkout. Once our team of experts confirm you’re good to go, we’ll send your prescription to our pharmacy, and they will ship directly to you.

No. Lab tests fluctuate and don't tell the whole story. If you’re experiencing symptoms, that’s the signal. We focus on how you feel—not just what your labs say.

Yes. After you complete the health quiz, a board-certified physician reviews your clinical history to determine if Oestra® is right for you. If approved, your prescription is filled and shipped to your door.

Most other HRTs focus on hormone levels individually. We take a more comprehensive approach, focusing on the ratios of estrogen, progesterone, and testosterone to bring them into balance—addressing the full spectrum of symptoms more effectively.

Yes. You have 6 full months to decide if Oestra® is right for you. If you're not seeing results, we’ll refund you—no questions asked.

Safety & Ingredients

Yes. Estradiol and progesterone are FDA-approved for treatment because they have been tested for safety and efficacy. Extensive research—including 100+ high-quality trials and large-scale observational studies—demonstrates their safety and benefits. There are also 200+ studies on vaginal administration showing protection of the endometrial lining.

Yes, it is absolutely safe. In fact, increasing estrogen in perimenopause can protect against heart disease, increase bone strength, and support overall vitality—beyond improving brain fog, vaginal dryness, and hot flashes.

Yes. All 503B compounding pharmacies (including ours) follow rigorous third-party testing and are regulated by the FDA, DEA, and state boards. Medications undergo potency, sterility, and quality checks before shipment.

Yes. Oestra® is compounded in a 503B FDA-regulated pharmacy that is also DEA-inspected and LegitScript certified. Each batch is tested for potency, purity, sterility, and consistency before shipping.

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