Menopause changed how you feel. Your hormones may simply need support.
Menopause Oestra® combines bioidentical estradiol and progesterone in one simple daily cream designed to support sleep, mood, energy, vaginal comfort, and long-term hormone health.
Take the 2-min Quiz
HSA/FSA eligible
Made in U.S.A
Compounded in a Licensed U.S. Pharmacy
503A U.S. pharmacy. NABP, LegitScript & PCAB certified.
Clinician-Approved Prescription
Clinician-Approved Prescription Treatment
HSA/FSA eligible. HIPAA-compliant & secure.
Bioidentical Estradiol + Micronized Progesterone
Bioidentical Estradiol + Micronized Progesterone
Clinically proven & third-party tested.
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
Menopause can affect more
than hot flashes.
If sleep has changed.
If anxiety feels unfamiliar.
If weight appears easier to gain.
If energy feels lower than it used to.
You’re not imagining it.
After menopause, estrogen, progesterone and testosterone levels fall significantly — affecting the brain, metabolism, sleep, libido, bones, heart, skin, and more.
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
Once a day application.
Hormone balance, simplified.
How Menopause Oestra® supports your body
Progesterone
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Progesterone
Estradiol
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Estradiol
Estradiol
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Estradiol
Ellagē® Base
Supports brain, bones, metabolism, mood, vaginal tissue, and long-term vitality.
Ellagē® Base
Ellagē® Base
Supports brain, bones, metabolism, mood, vaginal tissue, and long-term vitality.
Ellagē® Base
Bioidentical
Progesterone
Hormone Support
Bioidentical progesterone for protection and balance
Bioidentical
uterine support
calming support
Ingredient Sourcing
Compounded using pharmaceutical-grade ingredients sourced from US manufacturers.
Third-party labs verify that the strength in the bottle matches the prescription on the label.
Our active ingredients arrive with a Certificate of Analysis to confirm 100% purity.
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Bioidentical
Estradiol
Hormone Support
Bioidentical estradiol — the body’s most active estrogen
Bioidentical
systemic effect
plant-derived
Ingredient Sourcing
Compounded using pharmaceutical-grade ingredients sourced from US manufacturers.
Third-party labs verify that the strength in the bottle matches the prescription on the label.
Our active ingredients arrive with a Certificate of Analysis to confirm 100% purity.
Supports brain, bones, metabolism,
mood, vaginal tissue, and long-term
vitality.
Ellage® Anhydrous
Base
Delivery System
Ellage® anhydrous base for enhanced absorption
anhydrous
pH-balanced
stable delivery
Why it matters
100% paraben-free, fragrance-free and contains no endocrine disruptors.
Water-free and designed for sensitive vaginal tissue.
Enhances absorption, prevents leakage, and maintains natural pH for consistent systemic hormone levels.
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Supports Natural Testosterone
Hormone Pathway
Progesterone supports natural testosterone production
no synthetic t
self-regulated
downstream conversion
Why no added testosterone?
Progesterone is a precursor to testosterone.
Restoring it allows your body to regulate its own optimal levels — supporting libido, strength, and energy naturally.
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Bioidentical
Progesterone
Hormone Support
Bioidentical progesterone for protection and balance
Bioidentical
uterine support
calming support
Ingredient Sourcing
Compounded using pharmaceutical-grade ingredients sourced from US manufacturers.
Third-party labs verify that the strength in the bottle matches the prescription on the label.
Our active ingredients arrive with a Certificate of Analysis to confirm 100% purity.
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Bioidentical
Estradiol
Hormone Support
Bioidentical estradiol — the body’s most active estrogen
Bioidentical
systemic effect
plant-derived
Ingredient Sourcing
Compounded using pharmaceutical-grade ingredients sourced from US manufacturers.
Third-party labs verify that the strength in the bottle matches the prescription on the label.
Our active ingredients arrive with a Certificate of Analysis to confirm 100% purity.
Supports brain, bones, metabolism,
mood, vaginal tissue, and long-term
vitality.
Ellage® Anhydrous
Base
Delivery System
Ellage® anhydrous base for enhanced absorption
anhydrous
pH-balanced
stable delivery
Why it matters
100% paraben-free, fragrance-free and contains no endocrine disruptors.
Water-free and designed for sensitive vaginal tissue.
Enhances absorption, prevents leakage, and maintains natural pH for consistent systemic hormone levels.
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Supports Natural Testosterone
Hormone Pathway
Progesterone supports natural testosterone production
no synthetic t
self-regulated
downstream conversion
Why no added testosterone?
Progesterone is a precursor to testosterone.
Restoring it allows your body to regulate its own optimal levels — supporting libido, strength, and energy naturally.
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Hear from 5000+ women
4.9/5
5,695 Reviews
“I am concentrating and my critical thinking has improved...”
KAREN
VERIFIED PATIENT
“Oestra’s been life-changing, I have sex drive, my hair feels better, my skin feels better, I feel better overall. I cannot say enough.”
KATIE
VERIFIED PATIENT
“I’ve been in menopause for the last five miserable years and tried pills, herbs, and oils with no positive results. After starting Oestra, I noticed a change within the week. Two months in, I finally have my libido back and intimacy is no longer painful. I’m so glad I have my life back again.”
PATRICIA
VERIFIED PATIENT
“I’m sleeping through the night, my hot flashes are completely gone, my hair is growing again... I definitely would recommend Oestra.”
BRIDGETTE
VERIFIED PATIENT
“I’m four years post-menopause and this truly surprised me. It took about 11 days for my hot flashes to vanish and about 16 days for my libido to return. My brain fog has been lifting, my joint pain is better, and my sleep has improved. The medical assistant team has also been phenomenal.”
ANDREA
VERIFIED PATIENT
“I’m not uncomfortable anymore. It also helps with my irritability.”
KATHLEEN
VERIFIED PATIENT
“I already feel a lot of my pain decreasing, I’m sleeping better, and I’m able to mentally focus.”
ELANA
VERIFIED PATIENT
“My creativity has come back, my brain fog has lifted, I feel more level energy day in and day out.”
MEGAN
VERIFIED PATIENT
“I had already been dealing with PCOS. Same as perimenopause. I started getting hot flashes. Oestra® has helped so much already.”
RACHEL
VERIFIED PATIENT
“At 50, I started feeling the effects of menopause and struggled for years with weight gain, fatigue, anxiety, and no sex drive. Within just one week of trying Inner Balance, I started feeling a real difference. After years of doctor appointments and trying everything, I’m so glad I gave it a chance. I only wish I had tried it sooner.”
LEIGH
VERIFIED PATIENT
Is Menopause Oestra®
right for you?
It may be a fit if:
- You are in menopause, or close to menopause
- Your sleep, mood, or energy have changed
- You want bioidentical hormone therapy
- You prefer a non-oral delivery method
- You want long-term hormone balance
Designed for
long-term confidence
Oestra® is a prescription bioidentical hormone therapy compounded to rigorous U.S. standards.
What’s inside — and how it’s made — matters.
What most women notice
Week 2
Better sleep, improved mood,
and reduced vaginal dryness
Week 4
More consistent energy and
improved mental clarity
Week 6
Clearer thinking and reduced
anxiety.
Week 8
Feeling more like yourself again.
of women reported improvements in sleep, mood, vaginal comfort, and energy within 3 months.
*Individual results vary. Based on internal data.
Simple, transparent pricing
$199 per month$199/month for your first 6 months
Then $99.50 per month ongoing
Prescription treatment
Free & fast shipping
Unlimited clinical follow-up
HSA/FSA Eligible
No insurance needed, cancel anytime
Dose adjustments if needed
6-month money back guarantee
20% off any supplement in FullScript
Why delivery method matters
How estrogen enters the body determines how well it works.
Treatment
Liver metabolism
Dose required
Hormone levels
Side effects
Targeted support
Oestra® (Vaginal)
Bypasses liver
Lower, more efficient
Steadier absorption
Lower systemic burden
Direct + systemic benefit
Oral
Processed by liver
Higher due to breakdown
Peaks & Crashes
Higher nausea & clotting markers
Systemic only
Patch
Bypasses liver
Moderate
Can fluctuate with skin factors
Possible skin irritation
Systemic only
Oestra® works with your physiology — not against it.
No digestive breakdown. No first-pass liver metabolism.
Just efficient, steady estrogen support where it matters most.
take the 2-min quiz
Backed by science.
Formulated by women’s health experts.
Inner Balance was founded by Dr. Sarah Daccarett, MD, a board-certified specialist in women’s hormonal health and longevity medicine.
Her research has been published in leading medical journals, and she is licensed to practice medicine in 50 states.
“I founded Inner Balance because women deserve better
– better information, better care, and better outcomes.”
featured in
Real guidance from the
doctor behind Oestra®
Dr. Sarah created Inner Balance to deliver a different kind of hormonal care.
Her approach centers on bioidentical hormone enrichment, safe delivery methods, and treatment guided by how women actually feel - not just lab numbers.
After treating thousands of women, a clear pattern emerged — anxiety, poor sleep, brain fog, and low energy, often dismissed despite “normal” labs. Existing hormone therapy felt fragmented and overly complex. Oestra was created to simplify care and actually address how women feel.
Lab results don’t always reflect how hormones fluctuate in real life. Many women feel unwell despite being told everything is “normal.” Symptoms like brain fog, anxiety, and poor sleep are often more accurate indicators — and should guide treatment decisions.
Traditional hormone therapy often targets a few symptoms like hot flashes or sleep. Oestra takes a broader approach, supporting brain function, metabolism, energy, skin, and overall wellbeing. It’s designed to help women feel fully balanced — not just manage isolated symptoms.
Hormone therapy is often fragmented into multiple prescriptions, lab tests, and trial-and-error adjustments that can take years. Oestra® was designed to simplify the process into a single, streamlined approach that fits into your life without unnecessary complexity or cost.
Oestra® combines estradiol and progesterone into one daily treatment, replacing multiple prescriptions. This makes therapy easier to follow and more effective long term.
Estradiol and progesterone work together to support the entire body — including brain health, metabolism, skin, sleep, and the nervous system. Using both helps restore balance more effectively than treating hormones in isolation.
Vaginal delivery allows hormones to be absorbed directly into the bloodstream, supporting more stable levels and consistent symptom relief. Oral and topical methods are less efficient.
Many women notice early improvements in sleep and mood within weeks, with deeper changes like skin and cognitive function improving over 2–3 months.
Your care begins with a clinician reviewing your assessment. Your prescription is compounded and shipped directly to you, with ongoing adjustments and access to clinical support as your needs evolve.
Oestra® uses bioidentical estradiol and micronized progesterone, identical to the body’s natural hormones. Treatment is monitored and adjusted over time, focusing on safe, long-term support.
Oestra® restores progesterone, which the body can naturally convert into testosterone as needed. This supports balance without forcing levels and helps avoid side effects like acne, hair loss, or weight gain.
Oestra® is a prescription-based hormone therapy reviewed by a clinician and tailored to your symptoms. It’s compounded in a licensed pharmacy using pharmaceutical-grade ingredients.
Getting started is simple
Step 1
Complete our 2-minute health quiz
Help us understand your symptoms to see if Oestra® suits you.
Step 2
Receive your prescription treatment
Once approved, your meds ship to your door. No visit needed.
Step 3
Start treatment and get ongoing support
Our clinical care team is always here for you whenever you want to check in.
See If Oestra® Is Right for You
Free shipping. Cancel anytime. HSA/FSA Eligible.
You’re not managing this alone.
Every prescription is reviewed and monitored by a licensed clinician.
Hormones change. Your care adapts.
Unlimited
secured messaging
Lab review and
dose adjustments if needed
Ongoing monitoring
— not one-time prescribing.
Hormone balance.
Simplified.
One cream. Two bioidentical hormones.
Hormone balance made simple.
See If Oestra® Is Right for You
No insurance needed. Cancel anytime.
Questions?
TREATMENTS & SAFETY
Yes. Oestra® contains estradiol and progesterone—bioidentical hormones that are FDA-approved for use in treating hormone deficiency. It’s also delivered vaginally, a method backed by over 100 high-quality studies showing stable hormone levels, systemic benefits, and protection of the uterine lining. Safety isn’t just a promise—it’s clinically supported.
Yes. Hormone therapy is one of the most extensively studied treatments in medicine, with decades of research supporting its safety when used under medical supervision. Oestra® uses bioidentical estradiol and micronized progesterone — hormones identical to those naturally produced by your body — to support healthy hormone balance. If you ever choose to stop treatment, you can do so at any time. Your hormone levels will simply return to their natural baseline. Our medical team monitors your treatment and guides adjustments to ensure it remains safe and effective for you.
It goes beyond that. Oestra® is made by a 503B FDA-regulated compounding pharmacy that’s inspected by the FDA, DEA, and state licensing boards. Every prescription batch undergoes rigorous potency, purity, and safety checks before it ever reaches your door.
Yes, when they’re held to the highest regulatory standards—as ours is. Our partner pharmacy is LegitScript-certified, meaning it meets stringent quality and safety criteria. You’re getting the best of personalized medicine with pharmaceutical-grade oversight.
Oestra® uses only bioidentical hormones—compounds identical to the ones your body used to make, derived from plant sources. In plain terms: they’re natural to your body, better tolerated than synthetics, and designed to restore—not override—your natural balance.
Two major ways:
– Delivery: Oestra® is a vaginal cream, allowing for faster absorption and more stable hormone levels than oral pills or topical patches.
– Formulation: It’s an all-in-one treatment. One pump a day delivers estradiol, progesterone, and testosterone (via conversion), saving you from juggling 4–6 separate prescriptions.
Yes. Herbal supplements may temporarily ease symptoms, but they can’t restore hormone levels. Your body doesn’t make Dong Quai or Chaste Berry—it makes hormones. Oestra® gives your body what it actually needs, in the correct ratios, with prescription-level quality and precision.
No. Lab work is not required to begin treatment. Your care is guided first and foremost by your symptoms, medical history, and a comprehensive clinical review — not just lab numbers. Many hormone imbalances can be identified clinically, and you can begin treatment without testing. If you’d like deeper insight, we do offer convenient lab testing, and a full clinical review of your results is included in your care. Labs are optional — your journey with us will be personalized either way. You can start feeling better now, and add testing later if and when it makes sense for you.
No. In fact, Oestra® is designed to help correct estrogen dominance — not cause it. Estrogen dominance often occurs when progesterone levels are too low relative to estrogen. Oestra® provides both progesterone and estradiol in a carefully balanced ratio to help restore hormonal balance and calm the fluctuations that can drive symptoms. Because the hormones in Oestra® are delivered vaginally, they are absorbed efficiently and avoid the liver metabolism that can sometimes contribute to hormonal imbalances. This allows for more stable hormone levels and a more balanced response. Our medical team also personalizes dosing and monitors your progress to ensure your treatment remains balanced and effective for your body.
Most women tolerate Oestra® very well. As your body adjusts to hormone optimization, some women may experience mild breast tenderness or light cramping during the first few weeks. These symptoms are typically temporary and resolve quickly. Less common side effects may occur but are usually mild and easily addressed with simple adjustments to dosing or supportive recommendations. Our medical care team monitors your progress and is here to guide you every step of the way, ensuring your treatment remains comfortable, effective, and personalized to your needs.
No — Oestra® is non-contraceptive and does not suppress ovulation.
Yes. Bioidentical hormones are safe to take for decades and actually support longevity and disease prevention.
GETTING PRESCRIBED
Start by taking our health quiz. If you’re a candidate, you’ll move straight to checkout. After a licensed clinician reviews your info, your prescription is sent to the pharmacy and shipped directly to you. You’ll receive a 3-month supply as part of a monthly subscription.
Yes. Every Oestra® prescription is reviewed and approved by a licensed clinician. You don’t need to book a separate appointment - your quiz responses help us determine if it’s safe to begin treatment and ensure you're a good candidate for our starting dose.
We don’t isolate hormones - we balance them. Most HRT programs target estrogen, progesterone, or testosterone in isolation. Oestra® is different. It supports all three hormones together in the right ratios, to restore balance without the usual trial-and-error or side effects.
PRODUCT USE
Apply one pearl-sized pump of cream daily to vaginal tissue using your finger. An applicator will be available in the future, but for now, we recommend manual application for best results.
You may start noticing changes within the first 2–4 weeks—especially around mood, sleep, and vaginal dryness. Deeper shifts like energy, skin, and metabolism take longer, often 3–6 months or more. Oestra® isn’t a quick fix; it’s a full-body recalibration. But when balance returns, it’s worth the wait.
Oestra® is delivered every 3 months, and billed monthly. Your membership includes treatment, pharmacy processing, shipping, and unlimited clinical support.
ELIGIBILITY & ACCESS
Not at all. We work with women as young as 21. In fact, many women start in their 30s or 40s—often before traditional medicine recognizes hormone decline. The earlier you begin, the more protection you provide your bones, brain, heart, skin, and metabolism.
It’s not—because insurance typically only covers the most limited options. Oestra® replaces 5–6 prescriptions and is still more cost-effective than most HRT plans. HSA/FSA is also accepted at checkout.
Yes, we accept HSA/FSA directly at checkout. Most carriers accept prescriptions as eligible and we also provide a letter of medical necessity.
SHIPPING & DELIVERY
Yes. Shipping is always free—every Oestra® prescription ships at no extra cost.
Most orders ship within 3 business days after your prescription is approved. We like to give your pharmacy time to prepare everything safely.
Yes. Your order arrives in plain pharmacy-labeled packaging, with no mention of hormones or Inner Balance on the outside. Inside, you’ll find your medication and a pharmacy insert with usage guidance.