4.9/5
Trusted by 100,000+ women
Menopause weight gain Isn’t about what you’re eating.
It’s about estrogen.
When estrogen declines, your metabolism changes — how you
store fat, how you burn it, and the constant food noise in your brain. No amount of restricting fixes a hormonal system. Oestra does.
take the quiz
HSA/FSA eligible
Made in U.S.A
Compounded in a Licensed U.S. Pharmacy
503A U.S. pharmacy. NABP, LegitScript & PCAB certified.
Clinician-Approved Prescription
Clinician-Approved Prescription Treatment
HSA/FSA eligible. Secure.
Bioidentical Estradiol + Micronized Progesterone
Bioidentical Estradiol + Micronized Progesterone
Clinically proven & third-party tested.
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
How It Works
Estrogen isn’t just a reproductive hormone. It runs your metabolism.
The midsection weight isn’t random.
Declining estrogen shifts fat from subcutaneous (under the skin) to visceral (around your organs) — the kind no amount of sit-ups touches, because its cause is hormonal, not mechanical.
The food noise isn’t weakness.
Estrogen drives dopamine — the neurotransmitter that signals satisfaction. When estrogen drops, dopamine drops with it. Your brain searches for satisfaction through food. That is not a character flaw. It is a neurochemical signal.
The cravings aren’t random either.
Low dopamine drives cravings for sugar and ultra-processed food because they trigger a fast dopamine hit. The behavior isn’t a discipline failure. It’s the brain doing exactly what brains do when the reward system is depleted.
When estrogen is healthy, your body stores fat under the skin and burns it efficiently. When it declines — as it does in menopause — fat moves to your abdomen, insulin sensitivity drops, and your resting metabolism slows.
This is physiology, not failure.
See If bodymatched® Is Right for You
Women like this are not failing their diets. Their diets are failing them.
— Dr. Sarah Daccarett
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
Menopause can affect more
than hot flashes.
If sleep has changed.
If anxiety feels unfamiliar.
If weight appears easier to gain.
If energy feels lower than it used to.
You’re not imagining it.
After menopause, estrogen, progesterone and testosterone levels fall significantly — affecting the brain, metabolism, sleep, libido, bones, heart, skin, and more.
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
Once a day application.
Hormone balance, simplified.
How Menopause Oestra® supports your body
Progesterone
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Progesterone
Estradiol
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Estradiol
Estradiol
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Estradiol
Ellagē® Base
Supports brain, bones, metabolism, mood, vaginal tissue, and long-term vitality.
Ellagē® Base
Ellagē® Base
Supports brain, bones, metabolism, mood, vaginal tissue, and long-term vitality.
Ellagē® Base
Bioidentical
Progesterone
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Bioidentical
Estradiol
Supports brain, bones, metabolism,
mood, vaginal tissue, and long-term
vitality.
Ellage® Anhydrous
Base
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Supports Natural Testosterone
Progesterone serves as a precursor to
testosterone, supporting libido,
motivation, strength, and energy —
naturally and without another product.
Bioidentical
Progesterone
Protects the uterine lining, promotes restful sleep, balances estradiol, and supports a calm nervous system.
Bioidentical
Estradiol
Supports brain, bones, metabolism,
mood, vaginal tissue, and long-term
vitality.
Ellage® Anhydrous
Base
Engineered for vaginal absorption to enhance bioavailability, maintain natural pH, prevent leakage, and deliver stable systemic hormone levels.
Supports Natural Testosterone
Progesterone serves as a precursor to
testosterone, supporting libido,
motivation, strength, and energy —
naturally and without another product.
What women notice after starting Menopause Oestra®
Hear from 5000+ women
4.9/5
5,695 Reviews
“I am concentrating and my critical thinking has improved...”
KAREN
VERIFIED PATIENT
“Oestra's been life-changing, I have sex drive, my hair feels better, my skin feels better, I feel better overall. I cannot say enough.”
KATIE
VERIFIED PATIENT
“I've been in menopause for the last five miserable years and tried pills, herbs, and oils with no positive results. After starting Oestra, I noticed a change within the week. Two months in, I finally have my libido back and intimacy is no longer painful. I'm so glad I have my life back again.”
PATRICIA
VERIFIED PATIENT
“I'm sleeping through the night, my hot flashes are completely gone, my hair is growing again... I definitely would recommend Oestra.”
BRIDGETTE
VERIFIED PATIENT
“I'm four years post-menopause and this truly surprised me. It took about 11 days for my hot flashes to vanish and about 16 days for my libido to return. My brain fog has been lifting, my joint pain is better, and my sleep has improved. The medical assistant team has also been phenomenal.”
ANDREA
VERIFIED PATIENT
“I'm not uncomfortable anymore. It also helps with my irritability.”
KATHLEEN
VERIFIED PATIENT
“I already feel a lot of my pain decreasing, I'm sleeping better, and I'm able to mentally focus.”
ELANA
VERIFIED PATIENT
“My creativity has come back, my brain fog has lifted, I feel more level energy day in and day out.”
MEGAN
VERIFIED PATIENT
“I had already been dealing with PCOS. Same as perimenopause. I started getting hot flashes. Oestra has helped so much already.”
RACHEL
VERIFIED PATIENT
“At 50, I started feeling the effects of menopause and struggled for years with weight gain, fatigue, anxiety, and no sex drive. Within just one week of trying Inner Balance, I started feeling a real difference. After years of doctor appointments and trying everything, I'm so glad I gave it a chance. I only wish I had tried it sooner.”
LEIGH
VERIFIED PATIENT
Is Menopause Oestra® right for you?
It may be a fit if:
- You are in menopause, or close to menopause
- Your sleep, mood, or energy have changed
- You want bioidentical hormone therapy
- You prefer a non-oral delivery method
- You want long-term hormone balance
Designed for
long-term confidence
Oestra® is a prescription bioidentical hormone therapy compounded to rigorous U.S. standards.
What’s inside — and how it’s made — matters.
Feel it week by week
Real changes. Backed by science. Felt by thousands of women.
90%
of women reported deeper sleep and resolved vaginal dryness within 3 months.
*Individual results vary. Based on internal data.
98%
of women said they felt a positive shift in overall mood and steadier energy throughout the day.
80%
shared that Oestra® improved their sleep and mental health.
Improvement in vaginal health, mood and sleep
98% of women reported deeper sleep and resolved vaginal dryness within 3 months.
Simple, transparent pricing
$199 per month for your first 6 months
Then $99.50 per month
Prescription treatment
Free & fast shipping
Unlimited clinical follow-up
HSA/FSA Eligible
No insurance needed
Dose adjustments if needed*
Cancel
anytime20% off any supplement in FullScript
*Dose adjustments may incur an additional cost.
Why delivery method matters
in menopause treatment
How estrogen enters the body determines how well it works.
Treatment
Liver metabolism
Dose required
Hormone levels
Side effects
Targeted support
Oestra® (Vaginal)
Bypasses liver
Lower, more efficient
Steadier absorption
Lower systemic burden
Direct + systemic benefit
Oral
Processed by liver
Higher due to breakdown
Peaks & Crashes
Higher nausea & clotting markers
Systemic only
Patch
Bypasses liver
Moderate
Can fluctuate with skin factors
Possible skin irritation
Systemic only
Oestra® works with your physiology —
not against it.
No digestive breakdown. No first-pass liver metabolism.
Just efficient, steady estrogen support where it matters most.
take the 2-min quiz
Dr. Sarah Daccarett, MD
Backed by science.
Formulated by women’s health experts.
Inner Balance was founded by Dr. Sarah Daccarett, MD, a board-certified specialist in women’s hormonal health and longevity medicine.
Her research has been published in leading medical journals, and she is licensed to practice medicine in 48 states.
“I founded Inner Balance because women deserve better
– better information, better care, and better outcomes.”
featured in
Real guidance from the
doctor behind Oestra®
Dr. Sarah created Inner Balance to deliver a different kind of hormonal care.
Her approach centers on bioidentical hormone enrichment, safe delivery methods, and treatment guided by how women actually feel - not just lab numbers.
After treating thousands of women, a clear pattern emerged — anxiety, poor sleep, brain fog, and low energy, often dismissed despite "normal" labs. Existing hormone therapy felt fragmented and overly complex. Oestra was created to simplify care and actually address how women feel.
Lab results don't always reflect how hormones fluctuate in real life. Many women feel unwell despite being told everything is "normal." Symptoms like brain fog, anxiety, and poor sleep are often more accurate indicators — and should guide treatment decisions.
Traditional hormone therapy often targets a few symptoms like hot flashes or sleep. Oestra takes a broader approach, supporting brain function, metabolism, energy, skin, and overall wellbeing. It's designed to help women feel fully balanced — not just manage isolated symptoms.
Hormone therapy is often fragmented into multiple prescriptions, lab tests, and trial-and-error adjustments that can take years. Oestra® was designed to simplify the process into a single, streamlined approach that fits into your life without unnecessary complexity or cost.
Oestra® combines estradiol and progesterone into one daily treatment, replacing multiple prescriptions. This makes therapy easier to follow and more effective long term.
Estradiol and progesterone work together to support the entire body — including brain health, metabolism, skin, sleep, and the nervous system. Using both helps restore balance more effectively than treating hormones in isolation.
Vaginal delivery allows hormones to be absorbed directly into the bloodstream, supporting more stable levels and consistent symptom relief. Oral and topical methods are less efficient.
Many women notice early improvements in sleep and mood within weeks, with deeper changes like skin and cognitive function improving over 2–3 months.
Your care begins with a clinician reviewing your assessment. Your prescription is compounded and shipped directly to you, with ongoing adjustments and access to clinical support as your needs evolve.
Oestra® uses bioidentical estradiol and micronized progesterone, identical to the body's natural hormones. Treatment is monitored and adjusted over time, focusing on safe, long-term support.
Oestra® restores progesterone, which the body can naturally convert into testosterone as needed. This supports balance without forcing levels and helps avoid side effects like acne, hair loss, or weight gain.
Oestra® is a prescription-based hormone therapy reviewed by a clinician and tailored to your symptoms. It's compounded in a licensed pharmacy using pharmaceutical-grade ingredients.
Getting started is simple
Step 1
Complete our 2-minute health quiz
Help us understand your symptoms to see if Oestra® suits you.
Step 2
Receive your
prescription treatment
A licensed clinician evaluates and determines next steps. Once approved, prescription is delivered.
Step 3
Start treatment and
get ongoing support
Our clinical care team is always here for you whenever you want to check in.
You’re not managing this alone.
Every prescription is reviewed and monitored by a licensed clinician.
Hormones change. Your care adapts.
Unlimited
secured messaging
Lab review and
dose adjustments if needed
Ongoing monitoring
— not one-time prescribing.
Hormone balance.
Simplified.
One cream. Two bioidentical hormones.
Hormone balance made simple.
See If Oestra® Is Right for You
No insurance needed. Cancel anytime.
Questions?
TREATMENTS & SAFETY
Yes. Oestra® contains estradiol and progesterone—bioidentical hormones that are FDA-approved for use in treating hormone deficiency. It’s also delivered vaginally, a method backed by over 100 high-quality studies showing stable hormone levels, systemic benefits, and protection of the uterine lining. Safety isn’t just a promise—it’s clinically supported.
Yes. Hormone therapy is one of the most extensively studied treatments in medicine, with decades of research supporting its safety when used under medical supervision. Oestra® uses bioidentical estradiol and micronized progesterone — hormones identical to those naturally produced by your body — to support healthy hormone balance. If you ever choose to stop treatment, you can do so at any time. Your hormone levels will simply return to their natural baseline. Our medical team monitors your treatment and guides adjustments to ensure it remains safe and effective for you.
It goes beyond that. Oestra® is made by a 503B FDA-regulated compounding pharmacy that’s inspected by the FDA, DEA, and state licensing boards. Every prescription batch undergoes rigorous potency, purity, and safety checks before it ever reaches your door.
Yes, when they’re held to the highest regulatory standards—as ours is. Our partner pharmacy is LegitScript-certified, meaning it meets stringent quality and safety criteria. You’re getting the best of personalized medicine with pharmaceutical-grade oversight.
Oestra® uses only bioidentical hormones—compounds identical to the ones your body used to make, derived from plant sources. In plain terms: they’re natural to your body, better tolerated than synthetics, and designed to restore—not override—your natural balance.
Two major ways:
– Delivery: Oestra® is a vaginal cream, allowing for faster absorption and more stable hormone levels than oral pills or topical patches.
– Formulation: It’s an all-in-one treatment. One pump a day delivers estradiol, progesterone, and testosterone (via conversion), saving you from juggling 4–6 separate prescriptions.
Yes. Herbal supplements may temporarily ease symptoms, but they can’t restore hormone levels. Your body doesn’t make Dong Quai or Chaste Berry—it makes hormones. Oestra® gives your body what it actually needs, in the correct ratios, with prescription-level quality and precision.
No. Lab work is not required to begin treatment. Your care is guided first and foremost by your symptoms, medical history, and a comprehensive clinical review — not just lab numbers. Many hormone imbalances can be identified clinically, and you can begin treatment without testing. If you’d like deeper insight, we do offer convenient lab testing, and a full clinical review of your results is included in your care. Labs are optional — your journey with us will be personalized either way. You can start feeling better now, and add testing later if and when it makes sense for you.
No. In fact, Oestra® is designed to help correct estrogen dominance — not cause it. Estrogen dominance often occurs when progesterone levels are too low relative to estrogen. Oestra® provides both progesterone and estradiol in a carefully balanced ratio to help restore hormonal balance and calm the fluctuations that can drive symptoms. Because the hormones in Oestra® are delivered vaginally, they are absorbed efficiently and avoid the liver metabolism that can sometimes contribute to hormonal imbalances. This allows for more stable hormone levels and a more balanced response. Our medical team also personalizes dosing and monitors your progress to ensure your treatment remains balanced and effective for your body.
Most women tolerate Oestra® very well. As your body adjusts to hormone optimization, some women may experience mild breast tenderness or light cramping during the first few weeks. These symptoms are typically temporary and resolve quickly. Less common side effects may occur but are usually mild and easily addressed with simple adjustments to dosing or supportive recommendations. Our medical care team monitors your progress and is here to guide you every step of the way, ensuring your treatment remains comfortable, effective, and personalized to your needs.
No — Oestra® is non-contraceptive and does not suppress ovulation.
Yes. Bioidentical hormones are safe to take for decades and actually support longevity and disease prevention.
GETTING PRESCRIBED
Start by taking our health quiz. If you’re a candidate, you’ll move straight to checkout. After a licensed clinician reviews your info, your prescription is sent to the pharmacy and shipped directly to you. You’ll receive a 3-month supply as part of a monthly subscription.
Yes. Every Oestra®prescription is reviewed and approved by a licensed clinician. You don’t need to book a separate appointment - your quiz responses help us determine if it’s safe to begin treatment and ensure you're a good candidate for our starting dose.
We don’t isolate hormones - we balance them. Most HRT programs target estrogen, progesterone, or testosterone in isolation. Oestra® is different. It supports all three hormones together in the right ratios, to restore balance without the usual trial-and-error or side effects.
PRODUCT USE
Apply one pearl-sized pump of cream daily to vaginal tissue using your finger. An applicator will be available in the future, but for now, we recommend manual application for best results.
You may start noticing changes within the first 2–4 weeks—especially around mood, sleep, and vaginal dryness. Deeper shifts like energy, skin, and metabolism take longer, often 3–6 months or more. Oestra® isn’t a quick fix; it’s a full-body recalibration. But when balance returns, it’s worth the wait.
Oestra® is delivered every 3 months, and billed monthly. Your membership includes treatment, pharmacy processing, shipping, and unlimited clinical support.
ELIGIBILITY & ACCESS
Not at all. We work with women as young as 18. In fact, many women start in their 30s or 40s—often before traditional medicine recognizes hormone decline. The earlier you begin, the more protection you provide your bones, brain, heart, skin, and metabolism.
It’s not—because insurance typically only covers the most limited options. Oestra® replaces 5–6 prescriptions and is still more cost-effective than most HRT plans. HSA/FSA is also accepted at checkout.
Yes, we accept HSA/FSA directly at checkout. Most carriers accept prescriptions as eligible and we also provide a letter of medical necessity.
SHIPPING & DELIVERY
Yes. Shipping is always free—every Oestra® prescription ships at no extra cost.
Most orders ship within 3 business days after your prescription is approved. We like to give your pharmacy time to prepare everything safely.
Yes. Your order arrives in discreet packaging. The outside of the box is labeled Inner Balance, but it does not identify the medication or indicate what’s inside.