Whole-body hormone therapy - done
in 10 seconds.
Oestra™ delivers bioidentical, clinically validated hormones through a fast, once-a-day application designed for systemic absorption. One simple formula that supports your mood, metabolism, sleep, libido, brain, and bones-all without juggling multiple products.
Maintaining Quality & Excellence
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
More info
FDA announcement
The FDA's decision reflects updated research confirming that hormone therapy are both safe and beneficial.
Estrogen is one of the most effective longevity interventions for women.
FDA announcement, November 2025
Women Report Whole Body Symptom Relief
The vaginal route isn’t just for dryness. It’s one of the most effective ways to deliver hormones to the entire body. Oestra™ is designed to be systemic—absorbing directly into the bloodstream for full-body impact, without burdening the liver or spiking estrone.
80%
Said they "finally felt like themselves again" by month 3
85%
Saw libido, focus, and vitality return by 12 weeks
98%
Less heavy &
painful periods
98%
Resolved
Vaginal Dryness
Tired of stacking pills, patches, and creams?
Most women are told to piece together their hormone care: a patch here, a pill there, a cream to top it off.
Oestra™ replaces the patchwork.
It uses vaginal delivery to bypass the liver, reduce side effects, and give you steady hormone levels for real symptom relief and uterine protection.
This isn’t about adding more hormones.
It’s about smarter delivery, so your body can finally use what it needs.
All-in-One
Formula
Balanced dosing,
not guesswork
Systemic absorption,
not just local
Full-body benefits
from one cream
Your first step
back to balance
Step 1Complete our
5-minute health quiz
Help us understand your symptoms to determine if Oestra™ is right for you.
Step 2Receive your
prescription treatment
Once approved, your meds ship to your door. No visit needed.
Step 3Start treatment and
get ongoing support
Our care team is always here for you whenever you want to check in.
Three bioidentical hormones.
One smarter cream.
Oestra™ delivers the 3 hormones your body needs to function at its best—formulated to match your biology and applied the way your body prefers.
Estradiol
Supports brain, bones, metabolism,
mood, and vaginal tissue.
Progesterone
Protects the uterus, promotes
restful sleep, balances estrogen
Ellagē® Base
Long-lasting, gentle, low-leakage,
pH-balanced vaginal delivery.
Bioidentical hormones — identical to what your body makes
No synthetics. No fillers. Just balance
Body-matched ratios, clinically calibrated
Invest in your best self
$199/month → first 6 months
Then just 50% off forever
From $99.50/mo
- 6 month money-back guarantee
- Cancel anytime
- Free shipping
- Personalized treatment plan
- Unlimited clinical follow-up
- HSA/FSA Eligible
Prescription-only product, prescribed by our board certified physicians. See one in 24-48 hrs. 90 day supply replenished every 90 days.
One cream.
Full-body benefits.
Oestra™ doesn’t just target one area of your health—it supports the systems that help you feel energized, clear-headed, and confident in your body. From mental wellbeing to metabolism and sex drive, the benefits are as wide-ranging as the hormones it restores.
Mental clarity & mood
- Sharper focus and clearer thinking
- More stable moods
- Reduced anxiety and inner calm
Energy & Sleep
- Deeper, more restful sleep
- Increased daily energy
- Better motivation and follow-through
Libido & Sexual Wellness
- Higher desire and sexual confidence
- Easier arousal and more pleasure
- Improved vaginal comfort
Cycle & Hormonal Harmony
- More predictable, lighter cycles
- Reduced PMS symptoms
- A sense of rhythm and hormonal stability
Metabolic & Long-term support
- Improved metabolism and body composition
- Stronger bones and better aging support
- Renewed vitality across all stages of life
Vaginal = local only?
That’s a myth.
The vaginal route isn’t just for dryness. It’s one of the most effective ways to deliver hormones to the entire body.
Oestra™ is designed to be systemic—absorbing directly into the bloodstream for full-body impact, without burdening the liver or spiking estrone.
Proven in Clinical Trials
Clinical studies consistently show that bioidentical estrogen and progesterone support sexual wellness, hormone balance, and long-term safety when used together. Oestra™ applies these same evidence-based principles to restore natural balance and vitality.
Don’t just take our word for it.
Oestra™ helps women of all ages reclaim their energy, libido, sleep, and clarity. Every story is different—but the results speak for themselves.
Eliminate symptoms in just a few weeks.
Most clients begin to see improvements in 4 to 8 weeks. Oestra™ helps to reset your baseline for wellbeing.
Eliminate symptoms in just a few weeks.
Most clients begin to see improvements in 4 to 8 weeks. Oestra™ helps to reset your baseline for wellbeing.
Week 2
Better sleep,
improved mood
Mood swings feel more manageable. A little energy returns.
Week 4
Increased energy,
reduced bloating
Bloating goes down, pain during sex or exercise starts to ease.
Week 6
Libido improves
Mental clarity sharpens. Fewer flare-ups after workouts or meals.
Week 8
Hormones stabilize,
vitality restored
Energy, mood, and comfort feel consistently better.
The right range.
Not too much. Never too little.
Oestra™ is designed to bring your levels back to where your body feels its best—not push them beyond it.
Hormone Balance Score: 10%
Estradiol
100–300 pg/mL
Progesterone
3-6 ng/mL
Testosterone
10-30 ng/dL
Balance is the goal. Not overload.
Real Women. Real Results.
After 6 months of use, Oestra™ delivers measurable improvements in symptom relief, wellbeing, and hormone levels.
Science-Backed Improvements in 4 to 8 weeks
98% Improved Vaginal Dryness
Oestra™ delivers bioidentical estradiol and progesterone directly through the vaginal mucosa — a route clinically shown to restore moisture, elasticity, and pH balance. Unlike oral or topical HRT, vaginal delivery offers localized and systemic relief where it’s needed most.
98% Report Better Bleeding Patterns
By optimizing the progesterone-to-estrogen ratio, Oestra™ regulates the endometrial lining, resulting in lighter, shorter, and more predictable cycles. Its vaginal formulation delivers hormones consistently to stabilize fluctuations that often drive heavy or irregular bleeding.
80% Deeper Sleep
Progesterone in Oestra™ supports the brain’s GABA receptors, promoting relaxation and deeper, uninterrupted sleep. Its vaginal delivery offers sustained overnight levels, helping to improve restfulness within the first few weeks.
78% Elevated Moods
Oestra™ balances estrogen and progesterone — two neuroactive hormones that regulate serotonin, dopamine, and cortisol. This improves emotional resilience and reduces hormonal anxiety, irritability, and low mood.
75% Clearer Skin & Better Hair
Oestra™ raises progesterone, which helps block DHT — a primary hormone driving adult acne, facial hair, and scalp thinning. It also improves collagen production, hydration, and elasticity, supporting visibly healthier skin and hair.
80% Improved Energy
Oestra™ replenishes the hormones that power mitochondrial health, thyroid function, and glucose metabolism. This helps reduce hormone-related fatigue and supports more stable, sustained energy throughout the day.
76% Increased Sex Drive & Arousal
Oestra™ allows your body to convert progesterone into testosterone — the hormone behind libido and arousal. With systemic hormone balance and improved vaginal tissue health, sexual desire often returns within weeks.
Designed by a Women’s Health Specialist
Dr. Sarah Daccarett spent over a decade treating hormone issues that mainstream medicine ignored. Oestra™ is the result—built to give women a safer, smarter, and more complete way to feel like themselves again.
Dr. Sarah Daccarett, MD Founder & CEO, Inner balance
“I founded Inner Balance because women deserve better – better information, better care, and better outcomes.”
— Dr, Sarah Daccarett
featured in
I finally feel like myself again
Oestra™ helps women of all ages reclaim their energy, libido, sleep, and clarity. Every story is different—but the results speak for themselves.
Support your libido
— without harsh side effects
Oestra™ contains no testosterone — but still helps restore it naturally. By raising your progesterone, it activates a pathway that boosts your body’s own testosterone production — safely and steadily.
Patches & Pills
Targets
root cause
Non-contraceptive
Supports fertility
Improves mood, sleep, libido
Fewer side effects
Doctor-personalized care
Relief
Timeline
4–8 weeks
Varies widely
At Inner Balance,
we have your back.
Oestra™ comes with more than just a treatment—it comes with a clinical team that listens, adjusts, and supports you every step of the way. Your hormones aren’t static. Your care shouldn’t be either.
Licensed clinician oversight
Your treatment is prescribed and monitored by a licensed women’s health provider.
6 month money-back guarantee
If you don’t feel better after 6 months of treatment, we’ll make it right—or refund you.
Secure messaging access
Ask questions, share updates, and get support directly from your care team.
Refills,
Delivered:
No need to chase down a prescription. We keep you covered.
Exclusive Access to Dr. Sarah’s Content:
Get early access to live sessions, new products, and hormone health content directly from Inner Balance’s founder.
Still have questions?
TREATMENT & SAFETY
Is Oestra™ safe to use?
Yes. Oestra™ uses FDA-approved bioidentical hormones, clinically proven to reduce symptoms and improve long-term health.
What are the side effects?
Some users experience breast tenderness or spotting in the early weeks. These are temporary and typically resolve on their own or with minor dosage adjustments.
Is Oestra™ bioidentical or synthetic?
Oestra™ is 100% bioidentical and plant-based—meaning it’s chemically identical to the hormones your body used to make.
How do you use Oestra™?
Apply a pearl-sized amount of the cream vaginally once a day. It absorbs quickly and gets to work fast—no pills, patches, or injections.
GETTING PRESCRIBED
Do I need a prescription for Oestra™?
Yes. Our board-certified physicians prescribe a starting dose based on your clinical history provided in our health quiz.
How do I get started?
Take our 5-minute quiz. If you’re eligible, we’ll ship your prescription directly to your door and guide you through every step.
ACCOUNT, SUBSCRIPTIONS, & BILLING
Is Oestra™ covered by insurance?
Not currently. However, it’s often more cost-effective than managing multiple prescriptions, supplements, and appointments. Plus, we offer a 6 month money-back guarantee.
If I don’t see results, can I get a refund?
Yes! We stand behind our product. If for any reason during the 6 months, you decide it’s not for you, you can simply request a full refund.
Do you accept HSA/FSA for payment?
Yes we do accept HSA and FSA payments! Learn more about using your HSA/FSA here.
Ready to get your balance back?
No more guessing. No more patchwork plans.
Just one treatment — finally delivered the way your body prefers.
Vaginal = Local Only?
That’s a Myth.
It absorbs into your whole body.
Vaginal hormone therapy bypasses the liver and delivers hormones systemically—not just locally.
- Markedly enhances systemic bioavailability by avoiding first-pass hepatic metabolism
- Near-complete absorption of estradiol and progesterone
- Far exceeds oral (10–20%) and topical (3–20%) absorption rates
- Results in more consistent serum hormone levels and better symptom control
It’s clinically more effective.
Vaginal delivery ensures stable, targeted hormone levels—leading to better outcomes.
- Delivers a more stable hormone profile than oral or topical routes
- Reduces hormonal fluctuations that trigger side effects
- Improves patient ease of use with direct application
- Recognized for superior symptom relief across energy, mood, libido, and sleep
It’s one of the safest routes available.
Vaginal hormone therapy avoids systemic risks by staying out of the liver.
- Doesn’t increase clotting factors or stroke risk
- Doesn’t elevate estrone levels
- Bypasses hepatic metabolism entirely
- Backed by over 50 clinical trials showing controlled, safe absorption through the vaginal mucosa
It protects your uterine lining.
Vaginal progesterone delivers local endometrial protection without unnecessary systemic exposure.
- Uses the “first uterine pass effect” to concentrate progesterone at the endometrium
- Enhances protection when paired with estradiol therapy
- Avoids the reduced bioavailability and side effects of oral progesterone
- Provides a more predictable progestogenic effect with minimal systemic impact
View References
- Eva Sanchez Armengol, et al. Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects. Journal of Pharmacy and Pharmacology, 2025; rgaf045.
- The North American Menopause Society. The 2022 hormone therapy position statement: no news is good news. The Journal of The North American Menopause Society, Vol. 29, No. 7, pp. 767–794
- Nappi, Rossella E. The 2022 hormone therapy position statement of The North American Menopause Society: no news is good news. The Lancet Diabetes & Endocrinology, Volume 10, Issue 12, 832–834.
- Dragoman, M., Petrie, K., et al. Pharmacokinetics of ethinyl estradiol and etonogestrel during extended use of a contraceptive vaginal ring. Contraception, Volume 86, Issue 3, 291–292.
- Yu Xin, et al. Uterine first-pass effect: Unlocking the potential of vaginally administered ritodrine-loaded drug delivery. European Journal of Pharmaceutical Sciences, Volume 204, 2025, 106945.
- American College of Obstetricians and Gynecologists (ACOG). Postmenopausal Estrogen Therapy Route of Administration and Risk of Venous Thromboembolism.
- Mitchel CM, Larson JC, Crandall CJ, et al. Association of Vaginal Estradiol Tablet With Serum Estrogen Levels in Women Who Are Postmenopausal: Secondary Analysis of a Randomized Clinical Trial. JAMA Network Open. 2022;5(11):e2241743.
- Tourgeman, David E., et al. Serum and tissue hormone levels of vaginally and orally administered estradiol. American Journal of Obstetrics & Gynecology, Volume 180, Issue 6, 1480–1483.
- Santen RJ, Mirkin S, Bernick B, Constantine GD. Systemic estradiol levels with low-dose vaginal estrogens. Menopause (New York, N.Y.) 2020 Mar;27(3):361–370.
- Wu Guolan, et al. Pharmacokinetic Properties of Three Forms of Vaginal Progesterone Administered in Either Single or Multiple Dose Regimen in Healthy Postmenopausal Chinese Women. Frontiers in Pharmacology, 2017.
- Packaging Label: Crinone® 4% and Crinone® 8% – FDA
- Stanczyk, Frank Z., Paulson, Richard J., Roy, Subir. Percutaneous administration of progesterone: blood levels and endometrial protection. The Journal of The North American Menopause Society, Vol. 12, No. 2, pp. 232–237.
- Levine, Howard, et al. Comparison of the pharmacokinetics of Crinone 8% administered vaginally versus Prometrium administered orally in postmenopausal women. Fertility and Sterility, Volume 73, Issue 3, 516–521.
- Srikrishna, S., Cardozo, L. The vagina as a route for drug delivery: a review. International Urogynecology Journal 24, 537–543 (2013).
- Drug Packaging Label: Etonogestrel and Ethinyl Estradiol Vaginal Ring.
- Cicinelli, Ettore, et al. “First uterine pass effect” is observed when estradiol is placed in the upper but not lower third of the vagina. Fertility and Sterility, Volume 81, Issue 5, 1414–1416.
- Mary Beth Dorr, Anita L. Nelson, Philip R. Mayer, Radhika P. Ranganath, Paul M. Norris, Eileen C. Helzner, Richard A. Preston. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. Fertility and Sterility, Volume 94, Issue 6, 2010, Pages 2365–2368.
- Sriprasert I, Mert M, Mack WJ, Hodis HN, Shoupe D. Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women. Maturitas, 2021 Dec;154:13–19.
- Howard N., et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol for the ELITE Research Group. New England Journal of Medicine, 2016;374:1221–1231.
