- Cancel anytime
- 6 month money-back guarantee
- 20% off supplements via Fullscript
- HSA/FSA Eligible
Menopause Oestra™
This is full-body hormone therapy-delivered smarter. Finally, hormone therapy made for your stage of life.
Menopause Oestra™ is a low, steady,
bioidentical hormone formula created specifically for women 50+ who want relief from menopausal symptoms-
without the liver burden, fluctuations, or frustrations of traditional hormone options.
- Cancel anytime
- HSA/FSA Eligible
- 6 month money-back guarantee
- 20% off supplements via Fullscript
One simple daily pump
- Bioidentical estradiol + progesterone
- Vaginal delivery for superior absorption
- Steady hormone levels-no daily swings
- Designed to protect the uterus
Ingredients
Each measured daily pump contains:
- 0.5 mg Estradiol
- 50 mg Progesterone
This ratio is purposefully balanced to:
- Relieve menopausal symptoms
- Protect the uterine lining
- Avoid hormone liver metabolites that cause side effect
- Be appropriate for women starting-or restarting-HRT later in life
This is not a “microdose” that does nothing, and not an aggressive dose that overwhelms your system.
Why Menopause Oestra™ is different
Most hormone therapies weren’t designed to be simple, effective & whole body.
- Patches deliver uneven absorption
- Pills are poorly absorbed and strain the liver
- Standard HRT dosing often starts too low to help with all symptoms
Menopause Oestra™ was intentionally formulated as a starting dose for women over 50, supporting your body gently, safely, and effectively.
- ✓ Bioidentical estradiol + progesterone
- ✓ Vaginal delivery for superior absorption
- ✓ Steady hormone levels-no daily swings
- ✓ Designed to protect the uterus
- ✓ No pills, patches, or injections
Why vaginal hormone therapy is safer and more effective
Vaginal delivery isn’t “local-only.”
It’s systemic-and superior.
- Higher bioavailability than pills or creams
- More consistent absorption than patches
- No liver strain
- Lower estrone production (linked to side effects)
- Strong endometrial protection through progesterone’s first-uterine pass effect.
This is why vaginal estradiol + progesterone is widely
supported in modern hormone research.
What symptoms can Menopause Oestra™ help with?
Menopause Oestra™ is designed to address the
full-body effects of hormone loss, including:
- Hot flashes & night sweats
- Insomnia & fatigue
- Anxiety, low mood & irritability
- Brain fog & memory changes
- Vaginal dryness & discomfort
- Low libido
- Joint & muscle pain
- Dry skin, eyes & hair
- Weight redistribution
Hormone therapy designed for your whole body
Most hormone therapies treat symptoms only and don’t support the whole body. Menopause Oestra™ was designed to deliver whole-body relief for women over 50.
One formulation, one delivery method, working with your body-not against it.
76%
Report improved libido, arousal and sex drive
80%
Said they "finally felt like themselves again" by month 3
90%
Reported improved hot flashes, sleep, energy, and mood within 6 weeks.
98%
Resolved
Vaginal Dryness
A hormone enrichment cream created for women over 50
Whole-body hormone support, prescribed to help you feel like yourself again.
Oestra™ replaces the patchwork.
Oestra™ is a physician-developed, bioidentical hormone cream that restores estrogen and progesterone through vaginal delivery – a route clinically shown to improve absorption and reduce side effects.
A single all-in-one solution replacing a patchwork of different products.
Balanced dosing
without guesswork
Helps with mood, sleep, skin, libido, and energy.
Systemic support for your whole body - not just vaginal relief.
Your first step back to balance
Step 1Complete our
2-minute health quiz
Help us understand your symptoms to see if Oestra™ suits you.
Step 2Receive your
prescription treatment
Once approved, your meds ship to your door. No visit needed.
Step 3Start treatment and
get ongoing support
Our care team is always here for you whenever you want to check in.
One cream. Full-body benefits.
Oestra™ doesn’t just target one area of your health-it supports the systems that help you feel energized, clear-headed, and confident in your body. From mental wellbeing to metabolism and sex drive, the benefits are as wide-ranging as the hormones it restores.
Libido & Sexual Wellness
- Deeper, more restful sleep
- Increased daily energy
- Better motivation and follow-through
Mental clarity & mood
- Sharper focus and clearer thinking
- More stable moods
- Reduced anxiety and inner calm
Energy & Sleep
- Higher desire and sexual confidence
- Easier arousal and more pleasure
- Improved vaginal comfort
Hot flashes & night sweats
- Fewer and less intense hot flashes
- More restful, uninterrupted sleep
- Improved comfort and temperature balance
Disease prevention
- Bone protection
- Heart protection
- Muscle protection
Metabolic &
Long-term support
- Improved metabolism and body composition
- Stronger bones and better aging support
- Renewed vitality across all stages of life
Invest in your best self
$199/month → first 6 months
Then just 50% off forever
From $99.50/mo
- Cancel anytime
- 6 month money-back guarantee
- Free shipping
- Clinician-approved prescription
- Unlimited clinical follow-up
- HSA/FSA Eligible
Prescription-only product, prescribed by our board certified physicians. See one in 24-48 hrs. 90 day supply replenished every 90 days.
Three bioidentical hormones. One smarter cream.
Oestra™ delivers the 3 hormones your body needs to function at its best-formulated to match your biology and applied the way your body prefers.
Estradiol
Supports brain, bones, metabolism,
mood, and vaginal tissue.
Progesterone
restful sleep, balances estrogen
Ellagē® Base
pH-balanced vaginal delivery.
Bioidentical hormones - identical to what your body makes
No synthetics. No fillers. Just balance
Body-matched ratios, clinically calibrated
Start here.
Adjust only if needed.
Menopause Oestra™ is a gentle starting dose of hormone therapy designed for women over 50.
For many women, it’s enough to relieve symptoms on its own. If you need more support, our clinical team can safely adjust your hormones-or guide you to Oestra™ when appropriate.
No guessing. No rushing. Just the right support, step by step.
A Smarter Way to Restore Testosterone
Oestra™ contains no testosterone – but still helps restore it naturally. By raising your progesterone, it activates a pathway that boosts your body’s own testosterone production – safely and steadily.
Back to yourself
in just a
few weeks
As hormones stabilize, symptoms like fatigue, hot flashes and brain fog may start to ease.
Week 2
Sleep improves, mood lifts
Falling asleep is easier. Waking up feels less jarring.
Week 4
Hot flashes ease, focus clears
Temperature swings calm and brain fog begins to clear.
Week 6
Energy builds, skin softens
Mental clarity sharpens. Fewer flare-ups after workouts or meals.
Week 8
Libido lifts, body feels better
Intimacy improves and workouts feel less taxing.
*Individual results may vary. Based on internal survey. These statements have not been evaluated by the FDA.
Smarter care,
at a fraction of the cost
Replace patches, pills, and pellets with Oestra™ for better results with fewer side effects.
Oestra™
Patches & Pills
No liver burden
All-in-one treatment
Protects the uterus
Doctor-personalized care
Fewer side effects
Improves mood, sleep, libido
Relief timeline
4–8 weeks
Varies widely
Real Women. Real Results.
After 6 months of use, Oestra™ delivers measurable improvements in symptom relief, wellbeing, and hormone levels.
8 weeks Progress Backed by Science & Data
98% Improved Vaginal Dryness
Oestra™ delivers bioidentical estradiol and progesterone directly through the vaginal mucosa – a route clinically shown to restore moisture, elasticity, and pH balance. Unlike oral or topical HRT, vaginal delivery offers localized and systemic relief where it’s needed most.
98% Report Better Bleeding Patterns
By optimizing the progesterone-to-estrogen ratio, Oestra™ regulates the endometrial lining, resulting in lighter, shorter, and more predictable cycles. Its vaginal formulation delivers hormones consistently to stabilize fluctuations that often drive heavy or irregular bleeding.
80% Deeper Sleep
Progesterone in Oestra™ supports the brain’s GABA receptors, promoting relaxation and deeper, uninterrupted sleep. Its vaginal delivery offers sustained overnight levels, helping to improve restfulness within the first few weeks.
78% Elevated Moods
Oestra™ balances estrogen and progesterone – two neuroactive hormones that regulate serotonin, dopamine, and cortisol. This improves emotional resilience and reduces hormonal anxiety, irritability, and low mood.
75% Clearer Skin & Better Hair
Oestra™ raises progesterone, which helps block DHT – a primary hormone driving adult acne, facial hair, and scalp thinning. It also improves collagen production, hydration, and elasticity, supporting visibly healthier skin and hair.
80% Improved Energy
Oestra™ replenishes the hormones that power mitochondrial health, thyroid function, and glucose metabolism. This helps reduce hormone-related fatigue and supports more stable, sustained energy throughout the day.
76% Increased Sex Drive & Arousal
Oestra™ allows your body to convert progesterone into testosterone – the hormone behind libido and arousal. With systemic hormone balance and improved vaginal tissue health, sexual desire often returns within weeks.
8 weeks Progress Backed by Science & Data
98% Improved Vaginal Dryness
Oestra™ delivers bioidentical estradiol and progesterone directly through the vaginal mucosa – a route clinically shown to restore moisture, elasticity, and pH balance. Unlike oral or topical HRT, vaginal delivery offers localized and systemic relief where it’s needed most.
98% Report Better Bleeding Patterns
By optimizing the progesterone-to-estrogen ratio, Oestra™ regulates the endometrial lining, resulting in lighter, shorter, and more predictable cycles. Its vaginal formulation delivers hormones consistently to stabilize fluctuations that often drive heavy or irregular bleeding.
80% Deeper Sleep
Progesterone in Oestra™ supports the brain’s GABA receptors, promoting relaxation and deeper, uninterrupted sleep. Its vaginal delivery offers sustained overnight levels, helping to improve restfulness within the first few weeks.
78% Elevated Moods
Oestra™ balances estrogen and progesterone – two neuroactive hormones that regulate serotonin, dopamine, and cortisol. This improves emotional resilience and reduces hormonal anxiety, irritability, and low mood.
75% Clearer Skin & Better Hair
Oestra™ raises progesterone, which helps block DHT – a primary hormone driving adult acne, facial hair, and scalp thinning. It also improves collagen production, hydration, and elasticity, supporting visibly healthier skin and hair.
80% Improved Energy
Oestra™ replenishes the hormones that power mitochondrial health, thyroid function, and glucose metabolism. This helps reduce hormone-related fatigue and supports more stable, sustained energy throughout the day.
76% Increased Sex Drive & Arousal
Oestra™ allows your body to convert progesterone into testosterone – the hormone behind libido and arousal. With systemic hormone balance and improved vaginal tissue health, sexual desire often returns within weeks.
At Inner Balance,
we have your back.
Oestra™ delivers the 3 hormones your body needs to function at its best-formulated to match your biology and applied the way your body prefers.
Licensed clinician oversight
Your treatment is prescribed and monitored by a licensed women’s health provider.
6 month money-back guarantee
If you don’t feel better after 6 months of treatment, we’ll make it right-or refund you.
Secure messaging access
Ask questions, share updates, and get support directly from your care team.
Refills,
Delivered
No need to chase down a prescription. We keep you covered.
Exclusive Access to
Dr. Sarah’s Content
Get early access to live sessions, new products, and hormone health content directly from Inner Balance’s founder.
Still have questions?
TREATMENT & SAFETY
Is Oestra™ safe for
postmenopausal women?
Yes. Oestra™ uses FDA-approved bioidentical hormones, clinically proven to reduce symptoms and improve long-term health.
Why use vaginal delivery?
It offers better bioavailability and absorption, has fewer side effects, and results in more targeted results compared to other forms.
Will this make me start bleeding again?
Some women experience light bleeding and cramping as their uterine lining responds to hormones, but this is a short-term side effect that’s natural when hormones are re-introduced to our bodies. Our care team will guide and monitor you closely.
Do I need a lab test?
No. We personalize your treatment based on the symptoms and progress you share in our check-ins.-We don’t use arbitrary lab ranges.
GETTING PRESCRIBED
Do I need a prescription for Oestra™?
Yes. Oestra™ is a prescription medication. Once you take our quiz, our care team reviews your clinical history and prescribes a starting dose if you’re a fit.
How do I get started?
Take our 5-minute quiz to share your symptoms and hormone history. If eligible, your prescription will be sent to our pharmacy, and we’ll ship your treatment directly to your door.
Can I use Oestra™ with birth control?
We recommend avoiding oral birth control while using Oestra™. Non-hormonal methods like copper IUDs are safe and won’t interfere with your treatment.
HOW IT WORKS
How do you use Oestra™?
Oestra™ is a vaginal cream applied once daily-just a pearl-sized amount using either your finger or the included applicator. It absorbs through the vaginal wall and enters your bloodstream directly.
How is Oestra™ different from other hormone replacement therapies?
Unlike oral or topical HRT, Oestra™ uses vaginal delivery for up to 4x better absorption. It’s also an all-in-one product-supporting progesterone, estradiol, and testosterone balance in a single daily dose.
INSURANCE, PAYMENT & SUPPORT
Is Oestra™ covered by insurance?
Not currently. However, most patients find it more affordable than managing multiple prescriptions or supplements. Plus, we offer a 6 month money-back guarantee.
If I don’t see results, can I get a refund?
Yes. We offer a 6-month money-back guarantee so you can try Oestra™ risk-free. If you’re not seeing results, we’ll either adjust your plan or refund you in full.
Do you accept HSA/FSA for payment?
While we don’t process HSA/FSA directly on our site, many users successfully submit their receipts for reimbursement through their HSA/FSA provider.
Vaginal = Local Only?
That’s a Myth.
It absorbs into your whole body.
Vaginal hormone therapy bypasses the liver and delivers hormones systemically—not just locally.
- Markedly enhances systemic bioavailability by avoiding first-pass hepatic metabolism
- Near-complete absorption of estradiol and progesterone
- Far exceeds oral (10–20%) and topical (3–20%) absorption rates
- Results in more consistent serum hormone levels and better symptom control
It’s clinically more effective.
Vaginal delivery ensures stable, targeted hormone levels—leading to better outcomes.
- Delivers a more stable hormone profile than oral or topical routes
- Reduces hormonal fluctuations that trigger side effects
- Improves patient ease of use with direct application
- Recognized for superior symptom relief across energy, mood, libido, and sleep
It’s one of the safest routes available.
Vaginal hormone therapy avoids systemic risks by staying out of the liver.
- Doesn’t increase clotting factors or stroke risk
- Doesn’t elevate estrone levels
- Bypasses hepatic metabolism entirely
- Backed by over 50 clinical trials showing controlled, safe absorption through the vaginal mucosa
It protects your uterine lining.
Vaginal progesterone delivers local endometrial protection without unnecessary systemic exposure.
- Uses the “first uterine pass effect” to concentrate progesterone at the endometrium
- Enhances protection when paired with estradiol therapy
- Avoids the reduced bioavailability and side effects of oral progesterone
- Provides a more predictable progestogenic effect with minimal systemic impact
View References
- Eva Sanchez Armengol, et al. Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects. Journal of Pharmacy and Pharmacology, 2025; rgaf045.
- The North American Menopause Society. The 2022 hormone therapy position statement: no news is good news. The Journal of The North American Menopause Society, Vol. 29, No. 7, pp. 767–794
- Nappi, Rossella E. The 2022 hormone therapy position statement of The North American Menopause Society: no news is good news. The Lancet Diabetes & Endocrinology, Volume 10, Issue 12, 832–834.
- Dragoman, M., Petrie, K., et al. Pharmacokinetics of ethinyl estradiol and etonogestrel during extended use of a contraceptive vaginal ring. Contraception, Volume 86, Issue 3, 291–292.
- Yu Xin, et al. Uterine first-pass effect: Unlocking the potential of vaginally administered ritodrine-loaded drug delivery. European Journal of Pharmaceutical Sciences, Volume 204, 2025, 106945.
- American College of Obstetricians and Gynecologists (ACOG). Postmenopausal Estrogen Therapy Route of Administration and Risk of Venous Thromboembolism.
- Mitchel CM, Larson JC, Crandall CJ, et al. Association of Vaginal Estradiol Tablet With Serum Estrogen Levels in Women Who Are Postmenopausal: Secondary Analysis of a Randomized Clinical Trial. JAMA Network Open. 2022;5(11):e2241743.
- Tourgeman, David E., et al. Serum and tissue hormone levels of vaginally and orally administered estradiol. American Journal of Obstetrics & Gynecology, Volume 180, Issue 6, 1480–1483.
- Santen RJ, Mirkin S, Bernick B, Constantine GD. Systemic estradiol levels with low-dose vaginal estrogens. Menopause (New York, N.Y.) 2020 Mar;27(3):361–370.
- Wu Guolan, et al. Pharmacokinetic Properties of Three Forms of Vaginal Progesterone Administered in Either Single or Multiple Dose Regimen in Healthy Postmenopausal Chinese Women. Frontiers in Pharmacology, 2017.
- Packaging Label: Crinone® 4% and Crinone® 8% – FDA
- Stanczyk, Frank Z., Paulson, Richard J., Roy, Subir. Percutaneous administration of progesterone: blood levels and endometrial protection. The Journal of The North American Menopause Society, Vol. 12, No. 2, pp. 232–237.
- Levine, Howard, et al. Comparison of the pharmacokinetics of Crinone 8% administered vaginally versus Prometrium administered orally in postmenopausal women. Fertility and Sterility, Volume 73, Issue 3, 516–521.
- Srikrishna, S., Cardozo, L. The vagina as a route for drug delivery: a review. International Urogynecology Journal 24, 537–543 (2013).
- Drug Packaging Label: Etonogestrel and Ethinyl Estradiol Vaginal Ring.
- Cicinelli, Ettore, et al. “First uterine pass effect” is observed when estradiol is placed in the upper but not lower third of the vagina. Fertility and Sterility, Volume 81, Issue 5, 1414–1416.
- Mary Beth Dorr, Anita L. Nelson, Philip R. Mayer, Radhika P. Ranganath, Paul M. Norris, Eileen C. Helzner, Richard A. Preston. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. Fertility and Sterility, Volume 94, Issue 6, 2010, Pages 2365–2368.
- Sriprasert I, Mert M, Mack WJ, Hodis HN, Shoupe D. Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women. Maturitas, 2021 Dec;154:13–19.
- Howard N., et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol for the ELITE Research Group. New England Journal of Medicine, 2016;374:1221–1231.
